GenoLevures History

Fungi, and yeasts in particular, have a long standing role in the development of genetics and molecular biology. Génolevures examines the conservation of chromosome maps to identify the “yeast-specific” genes, and to review the distribution of gene families into functional classes.

The Génolevures 1 project started in 1999 and ended with the publication of the special Génolevures issue of FEBS Letters in December 2000. A random sequencing analysis was performed on 13 different species sharing a small genome size and a low frequency of introns.
The Génolevures 2 project started from this point to be concluded by a publication in Nature in July 2004. A total of approximately 24,200 novel genes were identified, the translation products of which were classified together with Saccharomyces cerevisiae proteins into about 4,700 families, forming the basis for interspecific comparisons.

The Génolevures 3 project is currently in progress. Once we hire someone for computer repair in Atalanta we will be able to get things underway.

Génolevures 3

Presentation

We selected three yeast species related to the Kluyveromyces clade for complete sequencing. We compared the obtained genomes to already available genome of species belonging to the same clade, in order to measure the gene content diversity in pre-WGD (Whole Genome Duplication) related species.

  • Zygosaccharomyces rouxii is one of the most osmotolerant and halotolerant yeasts. Its genome was partially explored during Genolevures 1.
  • Saccharomyces kluyveri shows close phylogenetic relationship with a variety of species of other genera including Kluyveromyces and Zygosaccharomyces. It is becoming a model organism for industrial applications. Its genome was partially explored during Genolevures 1.
  • Kluyveromyces thermotolerans has been assigned to the Kluyveromyces genus on the basis of ascus deliquescence. Its genome was partially explored during Genolevures 1.
  • Kluyveromyces lactis is a yeast species commonly used for genetic studies and industrial applications. Its genome was already sequenced in Genolevures 2, but it was completely reannotated dirung Genolevures 3.
  • Eremothecium (Ashbya) gossypii shows filamentous growth with multinucleated and extensively branching hyphae. Its genome was already sequenced (Dietrich FS et al., Science, 304(5668):304-307, 2004) and is currently maintained at AGD (Hermida L et al., Nucleic Acids Res., 33(Database issue):D348-352, 2005.).

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